Detergent-free Decellularized Nerve Grafts for Long-gap Peripheral Nerve Reconstruction

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Detergent-free Decellularized Nerve Grafts for Long-gap Peripheral Nerve Reconstruction

BACKGROUND Long-gap peripheral nerve defects arising from tumor, trauma, or birth-related injuries requiring nerve reconstruction are currently treated using nerve autografts and nerve allografts. Autografts are associated with limited supply and donor-site morbidity. Allografts require administration of transient immunosuppressants, which has substantial associated risks. To overcome these lim...

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A nerve gap is defined as the distance between two ends of a divided nerve. It is caused not just by the nerve tissue lost due to the trauma, or to the following debridement, but also by the actual retraction of the nerve stumps. The retraction is due to the elastic properties of the nerve fibers. Only small nerve gaps, in which minimal tension is required to contrast the elastic properties of ...

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ژورنال

عنوان ژورنال: Plastic and Reconstructive Surgery Global Open

سال: 2014

ISSN: 2169-7574

DOI: 10.1097/gox.0000000000000118